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Breakthrough in cancer research – Rational, personalized combination therapy against cancer driver genes - drugdiscovery.com


Breakthrough in cancer research – Rational, personalized combination therapy against cancer driver genes - drugdiscovery.com
There is a breakthrough now in cancer research and therapy providing personalized targeted drug combinations for cancer patients to treat the disease and overcome primary and secondary resistance due to multiple cancer driver gene targeting. The scientific concept is based on the identification and blocking of the cancer driver genes and the related cancer pathways for killing all the cancer cells. In this combination therapy approach first the cancer driver genes are identified, then combinations of compounds are tested in in vitro drug sensitivity assays. The compounds for testing are selected from the unique DriverHit Library™ of Vichem Chemie Research Ltd. developed specially for this purpose. This library includes targeted drugs, which are in clinical use already or in clinical development as unique, proprietary compounds. The in vitro validation of the predicted combinations will increase the probability of the successful therapy of the patient.

The goal in cancer treatment should be to eradicate all cancer cells permanently from a particular patient. The goal is to develop drugs that can eliminate certain types of cancer, via killing differentiated cancer cells and even cancer stem cells with the efficient inhibition of a certain set of driver genes and survival factors, thus inducing apoptosis. This therapeutic approach has to be accompanied by proper and sophisticated molecular diagnostics, utilizing genomics for identifying the driver genes in a particular tumor.

The DriverHitLibrary™ contains lead compounds against 114 driver gene related targets (for more than 140 targets) out of the identified 138 driver genes. Using a proper combination therapy against the identified driver genes in a particular cancer model all the cancer cells can be eliminated. There are 57 clinically approved drugs on the market now, which cover 55 driver genes. There are more than 2700 compounds in DHL™ including several hundreds novel patentable compounds, which can be utilized for drug development.

Tags: cancer drugs, cancer research, DriverHit Library, drug development, genes - December 2, 2014


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