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Unlocking-anticancer-potential-of-marketed-drugs-collection-of-in-vitroin-vivo-laboratory-and-clinical-data-updated-regularly
Unlocking anticancer potential of marketed drugs: collection of in vitro/in vivo laboratory and clinical data (updated regularly)
There are over 11,500 drugs licensed by the FDA and its foreign counterparts for treatment of human diseases. Screening of these agents for additional pharmacological activities may result in new therapeutic indications for existing drugs representing an innovative rout...
Tags: cancer, clinical trial, drug repositioning, drug repurposing...
August 27, 2014
Quiz-Fat-like-fat-dislike-Structure-related-lipophilicity-differences-of-statins
Quiz: Fat: like, fat: dislike - Structure related lipophilicity differences of statins
Statins are among the most widely prescribed drugs to control cardiovascular events in patients with pathologically elevated cholesterol level. Simvastatin and lovastatin were the first agents approved for clinical use in the 1980s. Statins competitively inhibit HMG-CoA...
Tags: HMG-CoA reductase inhibitor, lipophilicity, lovastatin, mevastatin, pravastatin, simvastatin...
August 23, 2014
Quiz-In-recognition-of-drug-chirality
Quiz: In recognition of drug chirality
Sulfinpyrazone is used to treat gout since decreases the serum uric acid level by increasing renal excretion. It is a chiral molecule and belongs to the pyrazolidine class of drug compounds.

Find the asymmetric center in the sulfinpyrazone molecule.

By...

Tags: asymmetric center, chirality, sulfinpyrazone...
August 12, 2014
Quiz-DNA-binding-of-flavonoids
Quiz: DNA binding of flavonoids
Several reports demonstrated the ability of plant derived dietary flavonoids to interact with nucleic acids. For instance, the typical flavonoid agent quercetin was found to be a DNA intercalator.

However, taxifolin, the close congener of quercetin exh...

Tags: DNA binding, flavonoids, intercalation, quercetin, taxifolin...
August 10, 2014
Quiz-When-the-negative-is-the-positive
Quiz: When the negative is the positive
Colour is an important parameter by which the quality of food and flavour are judged. The use of food colourants to make food more attractive and appetising has been in practice for centuries. Colourants were the first food additives subjected to governmental regulati...
Tags: anionic dye, cationic dye, food colourants...
August 6, 2014
Combating-stromal-chemoresistance-of-pancreatic-cancer
Combating stromal chemoresistance of pancreatic cancer
Distinctly from lung, breast, and prostate tumors that show improving mortality rates, the outcome of pancreatic cancer remains poor. Median survival from diagnosis is about nine months. Characteristic histological features of this therapy resistant cancer is an ext...
Tags: extracellular matrix, hyaluronic acid, interstitial pressure, pancreatic cancer, PEGylated hyaluronidase...
August 4, 2014
Quiz-Looking-for-chiral-centers-find-them-all
Quiz: Looking for chiral centers: find them all
Fosinopril is a phosphoryl-containing angiotensin converting enzyme (ACE) inhibitor used to treat high blood pressure. It prevents the conversion of angiotensin I to angiotensin II by blocking the enzyme. As an orally active ester prodrug, it is converted in the body to...
Tags: ACE inhibitor, chirality, fosinopril...
August 23, 2014
Experimental-treatments-for-Ebola-disease
Experimental treatments for Ebola disease
Ebola virus, along with its close relative the Marburg virus, makes up the family of negative stranded, RNA viruses known as Filoviridae (filamentous viruses). These extremely lethal, emerging pathogens cause a severe hemorrhagic fever in humans and non-human primates, ...
Tags: antisense, antiviral drugs, chloroquine, Ebola virus, experimental therapy, favipiravir, hemorrhagic fever, small interfering RNA...
August 20, 2014
A-novel-indication-of-cholesterol-lowering-drugs-strengthen-your-bones-by-statins
A novel indication of cholesterol-lowering drugs: strengthen your bones by statins
Statins are a class of commonly prescribed drugs that are the cornerstone of lipid-lowering therapy through the inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzyme. During hepatic cholesterol biosynthesis, these agents block competitively the c...
Tags: bone formation, bone fracture, lovastatin, osteoporosis, simvastatin, statins...
August 11, 2014
Globin-hunter-globulin
Globin hunter globulin
Preeclampsia (PE) is one of the most common complications of pregnancy. As a multi-system disorder, PE is still one of the dominating causes of maternal morbidity and mortality being responsible for 50,000-60,000 deaths/year worldwide. It may appear from 20 weeks of...
Tags: alpha1-microglobulin, endothelial damage, fetal hemoglobin, oxidative stress, pre-eclampsia...
August 8, 2014
Quiz-Nucleotides-wanted
Quiz: Nucleotides wanted
Flavin adenine dinucleotide (FAD) is an electron carrier molecule that acts as a coenzyme in living cells for a variety of biochemical reactions. According to its name, it contains two nucleotides.

Identify both nucleotides in the chemical struc...

Tags: coenzyme, dinucleotide, FAD...
August 6, 2014
Cancer-killers-Fat-burners
Cancer killers - Fat burners
Terpenic compounds are ubiquitous in a variety of vegetarian foods, medicinal herbs, and other plants. Ursolic and oleanolic acid are closely related lipophilic pentacyclic triterpenoids, distributed widely in herbal medicines and are used for medical purposes espec...
Tags: anticancer, natural product, oleanolic acid, skeletal muscle, triterpenoid, ursolic acid...
July 6, 2014
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