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Ibuprofen-side-effects
Ibuprofen side effects
Ibuprofen is widely administered drug possessing analgesic, antirheumatic, and antipyretic activities. Most frequently, it is prescribed for the treatment of rheumatoid arthritis, osteoarthritis, and other musculosketal disorders. It is also effective to reduce fever an...
Tags: antiinflammatory agents, asthama, ibuprofen, nonsteroidal, renal dysfunction, side effects...
October 31, 2014
Cardiac-glycosides-and-cancer-sometimes-bad-sometimes-good
Cardiac glycosides and cancer: sometimes bad, sometimes good
Cardiac glycosides are a large group of natural compounds found in both plants and animals. The most important plant-derived substances such as digitoxin, digoxin, ouabain, oleandrin and proscillaridin were isolated from the plant families Scrophulariaceae, Ap...
Tags: breast cancer, cardiac glycosides, digoxin, digitalis, endometrial cancer, estradiol, phytoestrogens, prostate cancer...
October 22, 2014
Chemotherapy-Drugs-for-Breast-Cancer
Chemotherapy Drugs for Breast Cancer
Cancer is the second leading cause of death and cancer of the breast is the most common form. The overall rate of this cancer is 1 in every 8 women. That statistic will change according to the woman’s age. Women at the age of 20 to 29 have a cancer rate ...
Tags: Chemotherapy drugs, breast cancer...
October 14, 2014
Kidney-Transplantation-Pipeline-Review-H2-2014
Kidney Transplantation - Pipeline Review, H2 2014
This report provides comprehensive information on the therapeutic development for Kidney Transplantation, complete with comparative analysis at various stages....
Tags: kidney transplant statistics, kidney transplant facts, kidney transplant research, kidney transplantation, kidney transplant review...
October 7, 2014
Mapping-serum-albumin-binding-sites-of-anticancer-drugs
Mapping serum albumin binding sites of anticancer drugs
Being the most abundant protein in plasma, the concentration of human serum albumin (HSA) is twice as great as the penultimately abundant immunoglobulin G. This large protein (66.5 kDa) is the endogenous vehicle for a diverse array of therapeutic drugs including antine...
Tags: anticancer drugs, binding site, human serum albumin...
October 6, 2014
Anticholesterol-Drugs
Anticholesterol Drugs
About one in three Americans suffer from high cholesterol, and less than half of these adults receive any sort of treatment for their condition. Individuals suffering from high cholesterol have twice the chance of developing heart diseases. Cholesterol under 200mg/dL is...
Tags: cholesterol, anticholesterol, anticholesterol drugs...
September 26, 2014
Re-using-old-drugs-against-Ebola-virus-disease
Re-using old drugs against Ebola virus disease
The Ebola virus is the causative agent for Ebola hemorrhagic fever showing person-to-person transmission through body fluids and oral exposure. With global impact, this deadly filovirus disease results in high morbidity and mortality in humans, with fatality rates of 80...
Tags: antiviral agents, drug repurposing, Ebola virus, hemorrhagic fever, tyrosine kinase inhibitor, virus entry...
October 25, 2014
Ceritinib-gained-accelerated-FDA-approval-for-treatment-of-non-small-cell-lung-cancer
Ceritinib gained accelerated FDA approval for treatment of non-small cell lung cancer
Anaplastic lymphoma kinase (ALK) was first discovered in anaplastic large cell lymphoma, where a chromosomal translocation induces the production of an oncogenic fusion protein consisting of the entire intracellular region of ALK fused to the echinoderm microtubule-as...
Tags: anaplastic lymphoma kinase, ceritinib, crizotinib, drug resistance, non-small cell lung cancer...
October 20, 2014
Quiz-Water-solubility-rule-for-an-anticancer-drug
Quiz: Water solubility rule for an anticancer drug
Tasisulam is novel anticancer agent displaying a remarkable antiproliferative activity across a broad range of human solid tumor cell lines. It is an acylsulfonamide compound with a unique dual mechanism of action mediated by both cytotoxic and antiangiogenic effects.<...
Tags: anticancer drug, tasisulam, water solubility...
October 11, 2014
Quiz-Daunorubicin-vs-idarubicin-a-methoxy-group-makes-the-difference
Quiz: Daunorubicin vs. idarubicin - a methoxy group makes the difference
Anthracycline antibiotics are the large family of natural quinone derivatives consisting of a neutral aglycone (dihydroxyanthraquinone) and an amino sugar moiety charged positively at physiological pH. These agents exhibit anticancer properties through DNA intercalation...
Tags: anthracycline antibiotics, daunorubicin, idarubicin, oral bioavailability...
October 6, 2014
Glioblastoma-multiforme-a-new-drug-forces-cancer-cells-to-drink-to-death
Glioblastoma multiforme: a new drug forces cancer cells to drink to death
Malignant gliomas are the most frequent and deadly cancers of the central nervous system. Gliomas can be categorized depending on the characteristic cell type of the tumor including pilocytic astrocytoma, diffuse astrocytoma, oligodendroglioma, anaplastic astocytoma, an...
Tags: antimalarial drugs, glioblastoma multiforme, macropinocytosis, quinoline, Vacquinol-1, vacuolization...
September 30, 2014
Long-live-the-king-a-novel-albumin-antibody-based-drug-delivery-platform-for-extension-short-plasma-half-life-of-therapeutic-peptides
Long live the king: a novel albumin-antibody-based drug-delivery platform for extension short plasma half-life of therapeutic peptides
Systematically administered therapeutic biopharmaceuticals (proteins, peptides) often have short half-lives in humans that considerably limit their pharmacological activity. By using protein engineering techniques, various half-life extension platforms have been develop...
Tags: AlbudAb, albumin, anti-albumin-binding domain antibody, diabetes, exendin-4...
September 25, 2014
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