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Cancer-killers-Fat-burners
Cancer killers - Fat burners
Terpenic compounds are ubiquitous in a variety of vegetarian foods, medicinal herbs, and other plants. Ursolic and oleanolic acid are closely related lipophilic pentacyclic triterpenoids, distributed widely in herbal medicines and are used for medical purposes espec...
Tags: anticancer, natural product, oleanolic acid, skeletal muscle, triterpenoid, ursolic acid...
July 6, 2014
Trojan-horses-of-the-iron-war
Trojan horses of the iron war
Iron is an essential cofactor for all cellular organisms. Successful proliferation of pathogenic bacteria and fungi in the human body depends on the acquisition of sufficient amounts of iron. However, the concentration of free iron in the extracellular fluids is ext...
Tags: antibacterial, iron chelator, siderophore, Trojan horse strategy...
July 1, 2014
Oral-delivery-of-curcumin-the-key-to-unleash-its-true-potency
Oral delivery of curcumin: the key to unleash its true potency
The yellow natural dye curcumin, a constituent of the spice turmeric, has been widely used in traditional Chinese medicine and Ayurveda since time immemorial. Pharmacological studies showed a variety of biological and pharmacological activities of curcumin, such as pote...
Tags: bioavailability, cancer, curcumin, liposome, nanoparticle, piperine...
June 28, 2014
Complementary-alternative-medicine-fermented-wheat-germ-extract
Complementary alternative medicine: fermented wheat germ extract
Avemar® is a biologically active, natural, non-toxic medical nutriment developed in Hungary in the early 1990s to complement conventional cancer therapy. It is an orally applicable fermented wheat germ extract (FWGE) containing a diverse array of chemical substances in...
Tags: antimetastatic, Avemar, cancer, fermented wheat germ extract, immunmodulation, nutrition supplement...
June 21, 2014
Quiz-Uric-acid
Quiz: Uric acid
Uric acid is produced by the catabolism of purines, that are the building blocks of nucleic acids. Elevated blood level of uric acid is associated with gout, when its salts, called urates, form crystals and are deposited in joints and soft tissues.

As its name i...

Tags: gout, urate salt, uric acid...
June 16, 2014
Quiz-Lipophilicity-of-doxorubicin
Quiz: Lipophilicity of doxorubicin

Doxorubicin and epirubicin are anthracycline antibiotics produced from a species of Streptomyces fungus. They are highly active agents against a variety of malignant tumors and are in clinical use for several decades.

From a structural p...

Tags: doxorubicin, epirubicin, configuration, lipophilicity, pKa, conformation...
June 14, 2014
Quiz-Anesthesia-chairs
Quiz: Anesthesia chairs
Ketamine is a dissociative anesthetic working as a non-competitive antagonist to the N-methyl D-asparate receptor (NMDA), an ionotropic receptor responsible for conducting electrical signals between the neurons and the brain. Ketamine binds to the allosteric phencyclidi...
Tags: conformation, ketamine, solubility...
July 3, 2014
Quiz-The-Janus-face-of-tetracyclines
Quiz: The Janus face of tetracyclines
Malignant pleural effusions are a common medical problem in patients with metastatic cancer producing distressing symptoms. Any primary tumour can potentially metastasise to the pleura but malignant pleural effusions are more frequently encountered with lung, breast and...
Tags: antibiotic, pleural effusion, pleurodesis, tetracycline...
June 28, 2014
Quiz-Are-anthocyanins-DNA-intercalators
Quiz: Are anthocyanins DNA intercalators?

It is the well known ability of several anticancer drugs to form stable complexes with native DNA (e.g., ellipticine, doxorubicin, mitoxantrone). Typically, such compounds consist of a flat, conjugated ring system which can readily intercalate betwe...

Tags: anthocyanins, deprotonation, DNA binding, flavylium cation, intercalation, pH dependence...
June 22, 2014
Quiz-Bile-pigments-with-a-small-difference
Quiz: Bile pigments with a small difference

As the first step of the enzymatic breakdown of heme, heme oxygenase cleaves the porphyrin ring to form biliverdin, which is subsequently converted to bilirubin by bilirubin reductase. Both pigment molecules contain two propionic acid side chains and differ ...

Tags: bile pigment, bilirubin, biliverdin, water solubility...
June 17, 2014
Algae-extract-brings-new-hope-to-cystic-fibrosis-patients
Algae extract brings new hope to cystic fibrosis patients
Cystic fibrosis (CF) is an inherited life-limiting exocrine disorder featured with abnormal ion transport affecting 70,000-80,000 individuals worldwide. Multiple organ systems are involved in CF including lung airways, as well as the digestive and genital tracts. Ab...
Tags: alginate oligosaccharide, bacterial biofilm, COPD, cystic fibrosis, nanomedicine, OligoG...
June 15, 2014
Quiz-About-curcumin-structure
Quiz: About curcumin structure
Curcumin is an anticancer phytochemical found in the spice turmeric with a variety of biological activities.

In research papers, its chemical structure is often displayed according to the formula above.

How this erroneous representation should b...

Tags: quiz, curcumin, structure...
June 12, 2014
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